蘭州大學研究生導師：何凱 正文

　　學習經歷

　　2008  美國俄克拉荷馬大學植物與微生物系  博士

　　2003  四川大學生命科學院  碩士

　　2000  四川大學生命科學院  學士

　　工作經歷

　　2013至今     蘭州大學生命科學學院  教授

　　2009-2013  美國加州大學伯克利分校植物與微生物系  博士后

　　2005-2008  美國俄克拉荷馬大學  教學助理

　　2003-2008  美國俄克拉荷馬大學  研究助理

　　教學及指導研究生情況

　　本科生《細胞信號轉導》教學

　　目前指導博士研究生4人，碩士研究生5人，已畢業碩士研究生4名

　　研究生主要研究方向：植物分子生物學、植物細胞信號轉導、植物逆境適應等

　　歡迎有志于科學研究的同學加盟！

　　發表論文及專著

　　(*corresponding author; §contributed equally)

　　Gao Y., Wu Y., Du J., Zhan Y., Sun D., Zhao J., Zhang S., Li J. and He K.* (2017) Both light-induced SA accumulation and ETI mediators contribute to the cell death regulated by BAK1 and BKK1. Frontiers in Plant Science 25;8:622. doi: 10.3389/fpls.2017.00622.

　　Wei, Z., Yuan, T., Tarkowská, D., Kim, J., Nam, H.G., Novák, O., He, K., Gou, X. and Li, J. (2017) Brassinosteroid biosynthesis is modulated via a transcription factor cascade of COG1, PIF4 and PIF5. Plant Physiology 174(2):1260-1273

　　He, K.*, and Wu, Y. (2016) Receptor-Like Kinases and Regulation of Plant Innate Immunity. Enzymes, 40:105-142

　　Ou, Y., Lu, X., Zi, Q., Xun, Q., Zhang J., Wu, Y., Shi, H., Wei, Z., Zhao, B., Zhang, X., He, K., Gou, X., Li, C., Li, J. (2016) RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana. Cell Research, 26(6), 686-698

　　Chen, L., Guan, L., Qian, P., Xu, F., Wu, Z., Wu, Y., He, K., Gou, X., Li, J., and Hou, S. (2016) NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016 Mar 17. pii: dev.129098.

　　Du, J., Gao, Y., Zan, Y., Zhang, S., Wu, Y., Xiao, Y., Zou, B., He, K., Gou, X., Li, G., Lin, H., Li, J. (2016) Nucleocytoplasmic trafficking is essential for BAK1 and BKK1-mediated cell-death control. Plant Journal 85(4), 520-531.

　　Wu, Y., Xun, Q., Guo, Y., Zhang, J., Cheng, K., Shi, T., He, K., Hou, S., Gou, X., Li, J. (2016) Genome-wide expression pattern analyses of the Arabidopsis leucine-rich repeat receptor-like kinases. Molecular Plant 9(2), 289-300.

　　Wu, W., Wu Y., Gao, Y., Li, M., Yin, H., Lv, M., Zhao, J., Li, J., He, K.* (2015) Somatic embryogenesis receptor-like kinase 5 in the ecotype Landsberg erecta of Arabidopsis is a functional RD LRR-RLK in regulating brassinosteroid signaling and cell death control. Frontiers in Plant Science 6:852. doi: 10.3389/fpls.2015.00852

　　Zheng X.§, He K.§, Kleist T., Chen F., Luan S. (2015) Anion channel SLAH3 functions in nitrate-dependent alleviation of ammonium toxicity in Arabidopsis. Plant, Cell and Environment Mar;38(3):474-86

　　Hou C., Tian W., Kleist T., He K., Garcia V., Bai F., Hao Y., Luan S., Li L. (2014) DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes. Cell Research 2014 Feb 7. doi: 10.1038/cr.2014.14.

　　He K., Xu S., Li J. (2013) BAK1 directly regulates brassinosteroid perception and BRI1 activation. Journal of Integrative Plant Biology 55(12), 1264–1270. ( Cover article)

　　Lee SC., Lim CW., Lan W., He K., Luan S. (2013) ABA signaling in guard cells entails a dynamic protein-protein interaction relay from the PYL-RCAR family receptors to ion channels. Molecular Plant 6:528-38.

　　Gou, X.§, Yin, H.§, He, K.§, Du, J., Yi., J., Xu, S. Lin, H., Clouse, SD., Li, J. (2012) Genetic Evidence for an Indispensable Role of Somatic Embryogenesis Receptor Kinases in Brassinosteroid Signaling. PLoS Genetics 8(1): e1002452. doi:10.1371/journal.pgen.1002452.

　　Li J., Du J., He K., Gou X. (2011). Control of cell death by Receptor Kinases in Arabidopsis thaliana. In "Receptor-like Kinases in Plants: From Development to Defense (eds Birgit Kemmerling and Frans Tax)". Signaling and Communication in Plants (ed. Frantisek Baluska, Springer Publisher), Volume 13, pp79-91.

　　Yang, H., Gou, X., He, K., Xi, D., Du, J., Lin, H., Li, J. (2010) Arabidopsis BAK1 and BKK1 confer reduced susceptibility to Turnip Crinkle Virus. European Journal of Plant Pathology 127: 147-156.

　　Gou, X., He, K., Yang, H., Yuan, T., Lin, H., Clouse, S.D., Li, J. (2010) Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana. BMC Genomics 11(1):19

　　He, K., Gou, X., Powell, R.A., Yang, H., Yuan, T, Guo, Z., and Li, J.(2008) Receptor-like protein kinases, BAK1 and BKK1, regulate a light-dependent cell-death control pathway. Plant Signaling & Behavior 3 (10), 813-815.

　　Wang, X., Kota, U., He, K., Blackburn, K., Li, J., Goshe, M.B., Huber, S.C., and Clouse, S.D.(2008) Sequential transphosphorylation of the BRI1/BAK1 receptor kinase pair impacts early events in brassinosteroid signaling. Developmental Cell 15, 220-235.

　　He, K., Gou, X., Yuan, T., Lin, H., Asami, T., Yoshida, S., Russell, S.D., Li, J. (2007) BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell death pathways. Current Biology 17, 1109-1115.

　　Heese, A., Hann, D.R., Gimenez-ibanex, S., Jones, A., He, K., Li, J., Schroeder, J.I., Peck, S.C., Rathjen, J.P. (2007) The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants. Proceedings of the National Academy of Sciences of the United States of America 104, 12217-12222.

　　Yuan, T., Fujioka, S., Takatsuto, S., Matsumoto, S., Gou, X., He, K., Russell, S.D., and Li, J.(2007) BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana. The Plant Journal 51 (2), 220–233.

　　研究方向

　　N Stress

　　Nitrate sensing/signaling

　　N Foraging

　　項目成果

　　主持科研項目：

　　國家自然科學基金面上項目“擬南芥受體激酶BAK1 和BKK1 介導細胞死亡分子機理”（No.31471305）2015-2018，80萬，主持，在研

　　中央高?；究蒲袠I務費專項資金-自由探索-面上項目“BED1依賴 MAPK 途徑調節植物花序發育”（lzujbky-2016-75）2016-2017，10萬，主持，結題

　　中央高?；究蒲袠I務費專項資金-科研創新團隊培育項目“植物免疫與逆境響應的分子機制”（lzujbky-2015-ct01）2015-2016，50萬，主持，結題

　　中央高?；究蒲袠I務費專項資金-自由探索-重點項目“擬南芥蛋白激酶 SnRK1 的生物學功能研究”（lzujbky-2015-k17）2015-2016，14萬，主持，結題

　　中央高?；究蒲袠I務費專項資金-自由探索-面上項目“擬南芥陰離子通道蛋白介導氮平衡的分子機理”（lzujbky-2014-84）2014-2015，10萬，主持，結題

　　參與科研項目：

　　國家作物轉基因重大專項子課題，2016ZX08009-003-002，2016-2018，70萬，參與，在研

　　國家自然科學基金植物激素作用的分子機理重大研究集成項目“ BAK1 調控油菜素內酯（BR）信號轉導及器官發育的分子機制”（91317311）2014-2015，200萬，參與，結題

 

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