中國藥科大學藥學院導師：錢海 正文

　　錢海 博士，副教授
　　2001年畢業于山東大學藥學院藥學專業，2007 獲中國藥科大學藥物化學專業博士學位。現任職藥學院新藥研究中心，主要從事藥物化學教學與新藥的設計合成及構效關系研究。2010年獲第13屆中國藥學會-施維雅青年藥物化學獎。

　　研究方向：
　　心腦血管藥物及多肽藥物的設計合成及生物活性研究。

　　科研項目：
　　現主持教育部科學技術研究重點項目和教育部博士點研究項目各一項，參與國家“十一五”新藥創制重大專項臨床前和候選藥物各一項，承擔企業橫向課題一項。

　　近期代表論著：
　　現已發表論文14篇（SCI收錄 13篇），申請專利 8 項（授權4項）。
　　1. Xiaoyun Zhu, Dandan Huang, Xiaobu Lan, Chunlei Tang, Yan Zhu, Jing Han, Wenlong Huang*, Hai Qian*. The first pharmacophore model for potent G protein-coupled receptor 119 agonist. European Journal of Medicinal Chemistry， 2011,46 (7), 2901–2907.
　　2. Zhi-hong Zou, Xiao-bu Lan, Hai Qian*, Wen-long Huang*, Yun-man Li. Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents.  Bioorganic & Medicinal Chemistry Letters，2011 , 21 (19), 5934–5938.
　　3. Bin Wang, Jing Li, Wen Long Huang*, Hui Bin Zhang, Hai Qian*, Yong Tang Zheng. Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents . Chinese Chemical Letters，2011, 22 (7),781–784.
　　4. Liang Ge, jingjie Wang, Xiaoyan Zhang, Huibin Zhang, Hai Qian*, Wenlong Huang and Jinpei Zhou*. Synthesis and Biological Evaluation of Nitric Oxide-releasing Derivatives of Capsaicin as Analgesia Drugs. Letters in Drug Design & Discovery, 2011, 8(1), 76-81.
　　5. Jinpei Zhou, Shuaijian Ni, Huibin Zhang, Hai Qian*, Yushi Chi, Wenlong Huang, Lu Yu, Xiaowen Hu and Wei Chen. Synthesis and Bioactivity Evaluation of Dipeptidyl Peptidase IV Resistant Glucagon-like Peptide-1 Analogues. Protein & Peptide Letters, 2010, 17 (10), 1290-1295.
　　6. Hai Qian, Zhixian Fu, Wenlong Huang, Huibin Zhang, Jinpei Zhou, Liang Ge*, Rui Lin, Haiyan Lin and Xiaowen Hu. Synthesis and Preliminary Biological Evaluation of Capsaicin Derivatives as Potential Analgesic Drugs. Medicinal Chemistry, 2010, 6(4), 205-210.
　　7. Hai Qian, Wei Chen, Xiaoyan Zhang, Huibin Zhang, Jinpei Zhou*, Wenlong Huang*, Jing Jin and Dongyan Dai. Synthesis and Biological Evaluation of Dihydroisoquinoline-2(1H)-Carbothioamide Derivatives as TRPV1 Antagonists. Letters in Drug Design & Discovery, 2010, 7(4), 235-237.
　　8. Hai Qian, Wei Chen, Jin Pei Zhou*, Wen Long Huang*, Hui Bin Zhang, Jing Jin. Total synthesis of endothelin 1 by microwave-assisted solid phase method. Chinese Chemical Letters. 2010, 21(4), 388-390.
　　9. Hai Qian, Zhixian Fu, Huibin Zhang, Jinpei Zhou*, Wenlong Huang*, Jing Jin, Wei Chen and Dongyan Dai. Synthesis and Biological Evaluation of Capsaicin Derivatives as Analgesia Drugs. Letters in Drug Design & Discovery, 2010, 7(2), 122-127.
　　10. Jian Feng Ji , Hui Bin Zhang, Wen Long Huang*, Hai Qian*, Jin Pei Zhou. A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors. Chinese Chemical Letters, 2010, 21 (1), 67-69.
　　11. Jinpei Zhou, Xiaowen Hu, Huibin Zhang, Hai Qian*, Wenlong Huang, Fan Qi and Yanchun Zhang. Synthesis and Biological Evaluation of 5,6-Dihydro- benzo[c] acridin-7-ol Derivatives as Anti-Alzheimer’s Disease Drugs. Letters in Drug Design & Discovery, 2009, 6(8), 623-628.
　　12. Jinpei Zhou, Huibin Zhang, Hai Qian*, Liang Lin, Wenlong Huang* and Shuaijian Ni. Synthesis and Biological Evaluation of Aromatase Inhibitors. Letters in Drug Design & Discovery, 2009, 6(3), 181-185.
　　13. 錢海,黃文龍,饒光玲,葛亮,吳曉明.香蕉皮中3-甲基-7, 8-二羥基異色滿酮-4的含量測定.中國藥科大學學報. 2009, 40(6): 524-526.
　　14. Qian, Hai; Huang, WenLong; Wu, XiaoMing; Zhang, HuiBing; Zhou, JinPei; Ye, WenCai, A new isochroman- 4-one derivative from the peel of Musa sapientum L. and its total synthesis. Chinese Chemical Letters, 2007, 18, (10), 1227-1230.

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