浙江大學生命科學學院生物科學系導師：吳雪昌 正文

　　姓名：吳雪昌
　　性別：男
　　所在學院：生命科學學院
　　職稱：教授

　　主要研究方向：
　　1．釀酒酵母（S.cerevisiae）抗逆與高產乙醇分子機制及適應逆境進化的機理研究；基因組結構變異與代謝工程等構建高效利用多種糖、抗逆高產乙醇的酵母工業菌株；大規模乙醇工業化生產節水節能減排高產，降低環境污染及生產成本的機制與技術集成研究。
　　2． 具藥用與保健功能生物源活性化合物的篩選、結構鑒定、藥理與生理功能研究；基因組水平挖掘發現新天然活性化合物及其生物合成基因（簇）、合成途徑解析與優化研究。
　　3．工業微生物產量性狀遺傳與關鍵基因的結構、表達調控與高產菌株的構建研究。

　　近3年SCI論文、著作（*：Corresponding author）
　　1．Tao XL1, Zheng DQ1, Liu TZ, Wang PM, Zhao WP, Zhu MY, Jiang XH, Zhao YH, and Wu XC* (2012). A Novel Strategy to Construct Yeast Saccharomyces cerevisiae Strains for Very High Gravity Fermentation. PLoS One, 7(2) :e31235
　　2．Wang PM, Zheng DQ, Liu TZ, Tao XL, Feng MG, Min H, Jiang XH, and Wu XC* (2012). Optimization of very-high-gravity fermentation in industrial Saccharomyces cerevisiae by glycerol metabolic engineering and improved genome shuffling. Bioresour Technol. (accepted).
　　3．Wang PM, Wu XC*, Chi XQ, Li YD, Zheng DQ, Ding R, and Min H (2011). Development and application of RAPD-SCAR markers to identify intra-species hybrids of industrial Saccharomyces cerevisiae. World J Microbiol Biotechnol, 27(1): 185-188.
　　4．Zheng DQ, Wu XC*, Tao XL, Wang PM, Li P, Chi XQ, Li YD, Yan QF, and Zhao YH (2011). Screening and construction of Saccharomyces cerevisiae strains with improved multi-tolerance and bioethanol fermentation performance. Bioresour Technol, 102(3): 3020-3027.
　　5．Zheng DQ, Wu XC*, Wang PM, Chi XQ, Tao XL, Li P, Jiang XH, and Zhao YH (2011). Drug resistance marker-aided genome shuffling to improve acetic acid tolerance in Saccharomyces cerevisiae. J Ind Microbiol Biotechnol, 38: 415-422.
　　6．Wang PM, Zheng DQ, Ding R, Chi XQ, Tao XL, Min H, and Wu XC*（2011）. Improvement of ethanol production in Saccharomyces cerevisiae by hetero-expression of GAPN and FPS1 deletion. J Chem Technol Biotechnol, 86: 1205-1210.
　　7．Wu XC*, Chi XQ, Wang PM, Zheng DQ, Ding R, and Li YD (2010). The evolutionary rate variation among genes of HOG-signaling pathway in yeast genomes. Biol Direct, 5: 46.
　　8．Chao-Dong Qian, Xue-Chang Wu*, Yi Teng, Wen-Peng Zhao, Ou Li, Sheng-Guo Fang, Zhao-Hui Huang and Hai-Chun Gao (2012). Battacin (Octapeptin B5), a New Cyclic Lipopeptide Antibiotic from Paenibacillus tianmuensis Active against Multidrug-resistant Gram-negative Bacteria. Antimicrobial Agents and Chemotherapy, 56(3):1458-1465.
　　9．Xue-Chang Wu*, Chao-Dong Qian, Hai-Huan Fang, Yan-Ping Wen, Jian-Ying Zhou, Zha-Jun Zhan, Rui Ding, Ou Li, Haichun Gao* (2011). Paenimacrolidin, a novel macrolide antibiotic from Paenibacillus sp. F6-B70 active against methicillin-resistant Staphylococcus aureus. Microbial Biotechnology, 4(4): 491-502.
　　10．Yanping Wen, Xuechang Wu*, Yi Teng, Chaodong Qian, Zhajun Zhan, Yuhua Zhao, Ou Li (2011). Identification and analysis of the gene cluster involved in biosynthesis of paenibactin, a catecholate siderophore produced by Paenibacillus elgii B69. Environmental Microbiology. 13(10): 2726-2737.
　　11．Rui Ding, Yudong Li, Chaodong Qian and Xuechang Wu* (2011). Draft Genome Sequence of Paenibacillus elgii B69, a Strain with Broad Antimicrobial Activity. Journal of Bacteriology 193 (17): 4537.
　　12．Rui Ding, Xue-Chang Wu*, Chao-Dong Qian, Yi Teng, Ou Li, Zha-Jun Zhan and Yu-Hua Zhao (2011). Isolation and identification of lipopeptide antibiotics from Paenibacillus elgii B69 with inhibitory activity against methicillin-resistant Staphylococcus aureus. J Microbiol. 49(6): 942-949
　　13．Xuechang Wu*, Haihuan Fang, Chaodong Qian, Yanping Wen, Xiaobo Shen, Ou Li, Haichun Gao* (2011). Paenibacillus tianmuensis sp. nov., isolated from soil of Tianmu Mountain National Natural Reserve in Zhejiang, China. Int J Syst Evol Microbiol. 61:1133–1137
　　14．Liang Zhu, Xuechang Wu*, Ou Li, Yamin Chen, Chaodong Qian, Yi Teng, Xianglin Tao, Haichun Gao (2011). Cloning and knockout of phytoene desaturase gene in Sphingomonas elodea ATCC 31461 for economic recovery of gellan gum. Journal of Industrial Microbiology and Biotechnology. 38:1507–1513.
　　15．Xuechang Wu*, Yamin Chen, Yudong Li, Ou Li, Liang Zhu, Chaodong Qian, Xianglin Tao, Yi Teng (2010). Constitutive expression of Vitreoscilla hemoglobin in Sphingomonas paucimobilis to improve gellan gum production. Journal of Applied Microbiology. 110(2): 422-430
　　16．Xuechang Wu*, Ou Li, Yamin Chen, Liang Zhu, Chaodong Qian, Yi Teng, Xianglin Tao (2010). A carotenoid-free mutant strain of Sphingomonas paucimobilis ATCC 31461 for the commercial production of gellan. Carbohydrate Polymers. 84(3): 1201-1207
　　17．Xue-Chang Wu*, Xiao-Bo Shen, Rui Ding, Chao-Dong Qian, Hai-Huan Fang & Ou Li (2010). Isolationand partial characterization ofantibiotics produced by Paenibacillus elgii B69. FEMS Microbiol Lett 310:32-38.
　　18．XuechangWu*, Ping Li, Chaodong Qian, Ou Li, Yinyan Zhou (2009). Trimeric coiled-coil domain of human pulmonary surfactant protein D enhances zinc-binding ability and biologic activity of soluble TRAIL. Molecular Immunology. 46(11-12): 2381-2388.
　　19．Yan-Ping Wen, Xue-Chang Wu*, Chao-Dong Qian, Yu-Hua Zhao, Hai-Huan Fang, Ou Li (2009). Bacillus tianmuensis sp nov., isolated from soil in Tianmu Mountain national natural reserve, Hangzhou, China. FEMS Microbiology Letters. 296(1): 26-30.
　　20．Ping Li, Jian Ying Zhou, Yin Yan Zhou, Chao Dong Qian, Ou Li, Hang Min*, Xue Chang Wu* (2009). The Coiled-coil Neck Domain of Human Pulmonary Surfactant Protein D Drives Trimerization and Stabilization of Thioredoxin, a Heterologous Non-collagenous Protein. Protein and Peptide Letters 16(3): 306-311.
　　21．閔航，吳雪昌，呂鎮梅，賈小明等 （2011） 《微生物學》，副主編，國家精品課程教材，浙江大學出版社.

　　國家發明專利：
　　1．吳雪昌. 一種抗腫瘤融合蛋白及其應用。 申請號：200810121475.0。
　　2．吳雪昌，錢朝東，李歐，方海環，周建英，白驊，杜加秋，林建秋. 一種多烯大環內酯類化合物及其制備與應用。申請號：CN200910153060。
　　3．錢朝東，李歐，沈小波，白驊，吳雪昌，杜加秋，林建秋. 一種多肽菌素及其制備與應用。申請號：201010268371。
　　4．錢朝東，李歐，丁銳，白驊，吳雪昌，杜加秋，林建秋. 一種廣譜多肽菌素及其應用。 申請號:201010554973。
　　5．吳雪昌，吳榮明，李 歐，朱 亮，陳亞敏，錢朝東，陳梅. 黃色素生成缺陷鞘脂單胞菌及其在結冷膠生產中的應用。申請號：CN200910153005。
　　6．吳雪昌，朱 亮，李 歐. 少動鞘氨醇單胞菌的八氫番茄紅素脫氫酶基因及其應用。申請號：201010506928.9。
　　7．吳雪昌，朱 亮，李 歐. 少動鞘氨醇單胞菌的crtZ基因、crtG基因及其應用。申請號：201110183602.1。
　　8．吳雪昌，朱 亮，李 歐. 少動鞘氨醇單胞菌的番茄紅素環化酶基因及其應用。申請號：201110184745.4。
　　9．吳雪昌,鄭道瓊，陶香林，王品美，劉天喆. 一株適合濃醪發酵的釀酒酵母菌株及其應用。 申請號：201110293252.4。
　　10．吳雪昌,王品美，鄭道瓊，陶香林，劉天喆. 低甘油合成、高酒精耐性的工業釀酒酵母菌株及其應用。 申請號：201110293244.X。

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