浙江大學醫學院導師：朱麗君 正文

　　姓名：朱麗君
　　性別：女
　　所在學院：醫學院
　　職稱：副教授

　　研究方向：
　　神經生物學，突觸傳遞的細胞和分子機制

　　學歷和研究經歷：
　　畢業于浙江醫科大學生物醫學工程系，畢業后分配到浙江醫科大學分子生物學實驗室工作，2002 年成立神經生物學教研室后轉入神經生物學教研室從事教學和科研工作，同年以同等學力考上博士研究生，2005年6月畢業，獲博士學位。
　　2003年3月至2005年4月公派赴美國City of Hope National Medical Center從事訪問學者研究工作，2006年11月至2007年2月赴香港科技大學生物化學系從事合作研究。
　　主要研究方向為離子型谷氨酸受體及其亞單位在中樞神經系統生理及病理過程中的作用。

　　近幾年主要科研項目：
　　1．神經元信息感受重要蛋白質膜轉運的結構基礎、調控及功能研究 國家重點基礎研究（973）2010CB912002, 2010.1-2014.12（學術骨干）
　　2．PICK1蛋白磷酸化位點的鑒定和磷酸化功能研究，浙江省自然科學基金 Y2090195 2010.1 – 2011.12 （負責人）
　　3．核糖核苷酸還原酶亞基特異性抗腫瘤藥物設計與生物活性研究。浙江省科技計劃項目，2008.1－2010.12(負責人)
　　4.白細胞介素-2參與海馬突觸傳遞和可塑性調節及其機制的研究, 國家自然科學基金項目, J20060472, 2007.1-2009.12 (負責人，已結題)

　　代表論文：
　　（1） Lijun Zhu, Bingsen Zhou, Xinhuan Chen et al. Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase. Biochemical Pharmacology 2009;78:1178-1185.
　　（2） Shao Xin*, Lijun Zhu*, Yubin Wang et al. Threonine 82 at the PDZ Domain of PICK1 is Critical for AMPA Receptor Interaction and Localization, Neurochemistry International (accepted) (* co-first author)
　　（3） Yi Shen, ShuangShuang Liu, MinYe Zhan, Jianhong Luo, Lijun Zhu. Interleukin-2 enhances dendritic development and spinogenesis in cultured hippocampal neurons. Anatomical Record (accepted) .
　　（4） Yi Shen*, Li-Jun Zhu*, Shuang-Shuang Liu, Su-Ya Zhou and Jian-Hong Luo. Interleukin-2 inhibits NMDA receptor-mediated currents directly and may differentially affect subtypes. Biochem Biophys Res Commun. 2006 Dec 15;351(2):449-54. (* co-first author)
　　（5） Min Guan, Lijun Zhu, George Somlo, et al. Bortezomib therapeutic effect is associated with expression of FGFR3 in multiple myeloma cells. Anticancer Res. 2009 Jan;29(1):1-9.
　　（6） Lijun Zhu, George Somlo, Bingsen Zhou, et al. Fibroblast Growth Factor Receptor 3 inhibited by short-hairpin RNAs Leads to Apoptosis in Multiple Myeloma. Molecular Cancer Therapeutics 2005 May;4(5):787-98
　　（7） Lijun Zhu, Yun Yen, Jimin Shao, et al.Fibroblast Growth Factor Receptor 3 Up-regulates Vascular Endothelial Growth Factor Expression In L6 Cells. International Journal of pharmacology 2(3): 324-330, 2006 .
　　（8） Zhu Lijun, Chen Z, Zhang LS, Xu SJ, Xu AJ, Luo JH. Spatiotemporal changes of the N-methyl-D-aspartate receptor subunit levels in rats with pentylenetetrazole-induced seizures. Neurosci Lett. 2004 Feb 6;356(1):53-6.
　　（9） Jimin Shao, Bingsen Zhou, Lijun Zhu, Weihua Qiu, Yate-Ching Yuan, Bixin Xi, and Yun Yen. In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase. Cancer Research 2004; 64: 1-6.
　　（10） Jimin Shao, Bingsen Zhou, Lijun Zhu, Angel J. Di Bilio, Leila Su, Yate-Ching Yuan, Shijun Ren, Eric J. Lien, Jennifer Shih, and Yun Yen. Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay. Biochemical Pharmacology 2005; 69: 627–634.
　　（11） Shao J, Zhou B, Di Bilio AJ, Zhu Lijun, Wang T, Qi C, Shih J, Yen Y. A Ferrous-Triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase.Mol Cancer Ther. 2006 Mar;5(3):586-92.
　　（12） Chung V, Zhou B, Liu X, Zhu Lijun, Boo LM, Nguyen HV, Ann DK, Song J, Chen Y, Yen Y. SUMOylation plays a role in gemcitabine- and bortezomib-induced cytotoxicity in human oropharyngeal carcinoma KB gemcitabine-resistant clone. Mol Cancer Ther. 2006 Mar;5(3):533-40.
　　（13） Xu SJ, Chen Z, Zhu Lijun, Shen HQ, Luo JH. Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats. Acta Pharmacol Sin. 2005 Feb;26(2):177-80.
　　（14） Chen zhong, Li Weidong, Zhu Lijun, Shen YingJie, Wei Erqing. Effects of histidine, a precursor of histamine, on pentylenetetrazole-induced seizures in rats Acta pharmacol Sin 2002;23(4) 361-366.
　　國際會議論文：
　　1. Lijun Zhu，Xin Shao, Huang WH, Wang YB, Yan XY, Zhu J, Shen Y, Xia J, Luo JH. Phosphorylation of PICK1 T82 is important for its interaction with GluR2 subunit of AMPA receptor and the receptor membrane trafficking. 2009 American society for neuroscience annual meeting, 2009/10/17-21.
　　2. Lijun Zhu, George Somlo, Bingsen Zhou, Jimin Shao, Jennifer Shih, Jianhong Luo Yun Yen. shRNA-induced inhibition of Fibroblast Growth Factor Receptor 3 in t(4;14) translocated multiple myeloma cells. Porc Amer Assoc Cancer Res, volume 45,2004.
　　3. Lijun Zhu, George Somlo, Bingsen Zhou, Jimin Shao, Kevin Clarke, Alison Hughes, Jianhong Luo, Yun Yen. Function of wild type fibroblast growth factor receptor 3 and Y373C, K650E mutants in human lymphoma U937 cells. Porc Amer Assoc Cancer Res, Volume 46,2005.
　　4. Jimin Shao, Bingsen Zhou, Lijun Zhu et al., In vitro high throughput screening assay of novel inhibitors with reconstituted ribonucleotide reductase holoenzyme. Porc Amer Assoc Cancer Res, volume 45,2004.
　　5. Min Guan, Lijun Zhu, George Somlo, Alison Hughes et al., Expression of wild type or specific mutations of FGFR3 in multiple myeloma cells is associated with variable PS-341 therapeutic effects. 98th AACR Annual Meeting—Apr 14-18, 2007; Los Angeles, CA
　　6. Jimin Shao, Bingsen Zhou, Lijun Zhu et al., Characterization of the interacting mechanisms between triapine and the small subunits of human ribonucleotide reductase. Porc Amer Assoc Cancer Res, Volume 46,2005.
　　7. JianHong Luo, Yu Gen, Lijun Zhu, D Ding Alternations in NMDA receptor subunit protein expression in different regions of rat brain following permanent ischemia Soc. Neurosci. Abstr. 1999;29:59 2
　　榮譽和獎項：
　　NMDA受體亞單位組成及其在發育過程中的表達 獲1999年度衛生部醫藥科技進步三等獎（排名第4）
　　參編教材：
　　網絡生物信息數據庫及相關軟件的應用。醫學分子細胞生物學--研究策略和技術原理。羅建紅主編。校內研究生教材

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