蘭州大學研究生導師：何永興 正文

　　學習經歷

　　2011/02-2013/02，加州大學伯克利分校，生物化學與分子生物學系（定量生物學研究所QB3），博士后

　　2005/09-2010/12，中國科大，生化與分子生物系，博士

　　2001/09-2005/07，中國科大，生命科學院，學士

　　工作經歷

　　2013/03-今，蘭州大學生命科學學院，副教授

　　教學及指導研究生情況

　　講授《生物信息學》

　　在讀研究生 4人

　　訪問學生   2人

　　畢業碩士3人，一人在上海交大醫學院讀博，一人在清華大學讀博，一人在湖南大學讀博。

　　發表論文及專著

　　2013年后發表文章(#通訊作者）：

　　Yan X, Yang R, Zhao RX, Han JT, Jia WJ, Li DY, Wang Y, Zhang N, Wu Y, Zhang LQ#, He YX#. The transcriptional regulator PhlH modulates 2,4-diacetylphloroglucinol biosynthesis in response to the biosynthetic intermediate and end product. Appl Environ Microbiol. 2017 Aug 18

　　Li L, Zhu Y, Zhou S, An X, Zhang Y, Bai Q, He YX#, Liu H#, Yao XJ#. Experimental and Theoretical Insights into the Inhibition Mechanism of Prion Fibrillation by Resveratrol and its Derivatives. ACS Chem Neurosci. 2017 Aug 17

　　Sun C, Yan K, Han JT, Tao L, Lv MH, Shi T, He YX, Wierzba M, Tax FE, Li J.Scanning for New BRI1 Mutations via TILLING Analysis. Plant Physiol. 2017 Jul;174(3):1881-1896.

　　Nan Q, Qian D, Niu Y, He YX, Tong S, Niu Z, Ma J, Yang Y, An L, Wan D, Xiang Y. Plant Actin-depolymerizing Factors Possess Opposing Biochemical Properties Arising From Key Amino Acid Changes Throughout Evolution. Plant Cell. 2017 Jan 25

　　Bo Xin, Geng Wu, Kunzhi Zhang, YX He, Hongzhi Tang, Chao Gao, Ping Xu and Cuiqing Ma Sequence similarity network analysis, crystallization, and X-ray crystallographic analysis of the lactate metabolism regulator LldR from Pseudomonas aeruginosa Bioresour. Bioprocess. (2016) 3: 32.

　　Wu D, Tao X, Chen ZP, Han JT, Jia WJ, Zhu N, Li X, Wang ZP#, He YX#. The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells. J Hazard Mater. 2016 Apr 15;307:193-201 (五年IF=5.277, JCR一區)

　　Zhang Z, Jiang YL, Wu Y, He YX#. Crystallization and preliminary X-ray diffraction analysis of a putative carbon-carbon bond hydrolase from Mycobacterium abscessus 103. Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):239-42.（IF=0.568, JCR四區）

　　Mu Y, Lian FM, Teng YB, Ao J, Jiang YL, He YX, Chen Y, Zhou CZ, Chen X. The N-terminal β-sheet of peroxiredoxin 4 in the large yellow croaker Pseudosciaena crocea is involved in its biological functions. PLoS One. 2013;8(2):e57061.（五年IF=4.015, JCR三區）

　　2013之前發表文章第一或共第一作者文章（*共同第一作者）：

　　He YX, Zhang NN, Li WF, Jia N, Chen BY, Zhou K, Zhang J, Chen Y, Zhou CZ. N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease. J Mol Biol. 2012 May 4;418(3-4):197-207.(五年IF=3.795, JCR二區)

　　Du Y*, He YX*, Zhang ZY, Yang YH, Shi WW, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ, Chen Y. Crystal structure of the mucin-binding domain of Spr1345 from Streptococcus pneumoniae. J Struct Biol. 2011 Apr;174(1):252-7.(五年IF=3.407, JCR二區)

　　He YX, Huang L, Xue Y, Fei X, Teng YB, Rubin-Pitel SB, Zhao H, Zhou CZ. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J Biol Chem. 2010 Feb 12;285(7):4603-11.（五年IF= 4.863，JCR二區）

　　He YX, Gui L, Liu YZ, Du Y, Zhou Y, Li P, Zhou CZ. Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly. Proteins. 2009 Jul;76(1):249-54.（五年IF=2.964，JCR三區）

　　Zhang WJ*, He YX*, Yang Z, Yu J, Chen Y, Zhou CZ. Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae. Proteins. 2008 Dec;73(4):1058-62.（五年IF=2.964，JCR三區）

　　其他文章：

　　Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC, Zhou CZ. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12487-92.

　　Ma G, Yu J, Xiao Y, Chan D, Gao B, Hu J, He YX, Guo S, Zhou J, Zhang L, Gao L, Zhang W, Kang Y, Cheah KS, Feng G, Guo X, Wang Y, Zhou CZ, He L. Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Res. 2011 Sep;21(9):1343-57.

　　Kang Y, He YX, Zhao MX, Li WF. Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1173-8.

　　Yang JP, Ma XX, He YX, Li WF, Kang Y, Bao R, Chen Y, Zhou CZ. Crystal structure of the 30 K protein from the silkworm Bombyx mori reveals a new member of the β-trefoil superfamily. J Struct Biol. 2011 Jul;175(1):97-103.

　　Du Y, Shi WW, He YX, Yang YH, Zhou CZ, Chen Y. Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC. Biochem J. 2011 Jun 1;436(2):283-9.

　　Zhang X, Teng YB, Liu JP, He YX, Zhou K, Chen Y, Zhou CZ. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochem J. 2010 Dec 15;432(3):445-50.

　　Du Y, He YX, Gaowa S, Zhang X, Chen Y, Zhang SC, Zhou CZ. Crystal structures of the apo and GDP-bound forms of a cupin-like protein BbDUF985 from Branchiostoma belcheri tsingtauense. Proteins. 2010 Sep;78(12):2714-9.

　　Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, Zhou CZ. Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. J Mol Biol. 2010 May 14;398(4):614-22.

　　Zhang NN, He YX, Li WF, Teng YB, Yu J, Chen Y, Zhou CZ. Crystal structures of holo and Cu-deficient Cu/Zn-SOD from the silkworm Bombyx mori and the implications in amyotrophic lateral sclerosis. Proteins. 2010 Jun;78(8):1999-2004.

　　Teng YB, Jiang YL, He YX, He WW, Lian FM, Chen Y, Zhou CZ. Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103. BMC Struct Biol. 2009 Oct 24;9:67.

　　Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Rep. 2009 Dec;10(12):1320-6.

　　Teng YB, Ma XX, He YX, Jiang YL, Du J, Xiang C, Chen Y, Zhou CZ. Crystal structure of Arabidopsis translation initiation factor eIF-5A2. Proteins. 2009 Nov 15;77(3):736-40.

　　Wang Y, He YX, Yu J, Zhou CZ. Cloning, overproduction, purification, crystallization and preliminary X-ray diffraction analysis of yeast glutaredoxin Grx5. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):651-3.

　　Huang L, Sun F, Liang C, He YX, Bao R, Liu L, Zhou CZ. Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidium. Proteins. 2009 May 1;75(2):524-7. doi: 10.1002/prot.22346.

　　Wang S, He YX, Bao R, Teng YB, Ye BP, Zhou CZ. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of hypothetical protein SCO4226 from Streptomyces coelicolor A3(2). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):847-50.

　　參與翻譯編寫《英漢生物技術詞典》，化學工業出版社

　　研究方向

　　我們利用蛋白質組學，蛋白質晶體學、熒光光譜學、計算生物學（如分子動力學模擬和分子對接）、分子生物學及生化等多種技術手段，研究微生物中的毒素-抗毒素系統，生物膜的形成以及微生物對化學信號的感受和識別機制和多重耐藥性。

　　項目成果

　　榮譽、獲獎

　　社會工作

　　其它信息

　　歡迎對微生物學和結構生物學感興趣的同學報考本實驗室研究生！

 

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