寧波大學醫學院導師：韓麗媛 正文

[導師姓名]
韓麗媛

[所屬院校]
寧波大學

[基本信息]
導師姓名：韓麗媛
性別：女
人氣指數：1092
所屬院校：寧波大學
所屬院系：醫學院
職稱：講師
導師類型：
招生專業：流行病與衛生統計學

[通訊方式]
電子郵件：hanliyuan@nbu.edu.cn

[個人簡述]
韓麗媛，講師，哈爾濱醫科大學醫學博士，杜蘭大學博士后，蘇州大學博士后。浙江省預防醫學會流行病學專業青年委員會委員?，F主持國家自然科學基金青年項目1項、浙江省自然科學基金項目2項、教育部人文社科項目1項、浙江省教育廳項目1項、寧波市自然科學基金1項等。參與編寫留學生流行病學英文版教材《預防醫學、醫學統計學和流行病學（英文版）》著作1部、大學本科教材《預防醫學》1部等。在國內外專業期刊發表學術論文25篇，其中SCI收錄23篇，關于糖尿病的研究成果以第一作者在國際著名學術期刊《Diabetologia》(SCI IF 6.973)發表，并被國際著名Elsevier 學術網站收錄為中國學者發表的重要研究論文?，F為Molecular Medicine Report及浙江預防醫學雜志審稿專家。主要研究方向：糖尿病及高血壓等慢性病的發病機制及流行病學研究。

[科研工作]
1、Liyuan Han Qunhong Wu Changyi Wang et al. Homocysteine, Ischemic Stroke, and Coronary Heart Disease in Hypertensive Patients A Population-Based, Prospective Cohort Study. Stroke.2015, DOI: 10.1161/STROKEAHA.115.009111
2、Changyi Wang, Liyuan Han*, Qunhong Wu et al. Association between homocysteine and incidence of ischemic stroke in subjects with essential hypertension: a matched case-control study. Clin Exp Hypertens, 2015,DOI: 10.3109/10641963.2015.1026039
3、Liyuan Han, Panpan Liu, Changyi Wang, Qilong Zhong, Rui Fan, Lin Wang*, Shiwei Duan* and Lina Zhang*. The interactions between alcohol consumption and DNA methylation of the ADD1 gene promoter modulate essential hypertension susceptibility in a population-based, case–control study. Hypertension Research. 2015 Jan 8. doi: 10.1038/hr.2014.172.
4、Han L,Zhang L,Xing W,Zhuo R,Lin X,Hao Y,Wu Q*,Zhao J*.The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility. J Diabetes Res.20142014:805801. doi: 10.1155/2014/805801. Epub 2014 Apr 28.
5、Li-Yuan Han, Kui Liu, Xia-Lu Lin, Bao-Bo Zou*, Jin-Shun Zhao*.Lack of Any Association of GST Genetic Polymorphisms with Susceptibility to Ovarian Cancer. Asian Pac J Cancer Prev. 2014 15(15):6131-6.
6、Han L,Tang L,Wang C,Chen Z,Zhang T,Chen S,Liu S,Peng X,Mai Y,Duan S*. Fat mass and obesity-associated gene rs11642015 polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index. Biomed Rep.2014 Sep2(5):681-686.
7、Han LY,Wu QH*,Jiao ML,Hao YH,Liang LB,Gao LJ,Legge DG,Quan H,Zhao MM,Ning N,Kang Z,Sun H. Associations between Single-nucleotide Polymorphism (+45 T>G, +276 G>T, -11377 C>G, -11391G>A) of Adiponectin Gene and the risk of Type 2 diabetes mellitus: a systematic review and meta-analysis, Diabetologia [J]. 2011,54(9): 2303-14
8、Changyi Wang , Qunhong Wu , Lina Zhang , Yanhua Hao , Rui Fan, Xiaolin Peng , Shengyuan Liu , Zhongwei Chen, Tao Zhang , Sihan Chen , Jianping Ma , Shiwei Duan , Liyuan Han*.Elevated Total Plasma Homocysteine Levels Are Associated with Type 2 Diabetes in Women with Hypertension. Asia Pacific Journal of Clinical Nutrition. 201524(4):683-91. doi: 10.6133/apjcn.2015.24.4.09.
9、ChangyiWang, Sihan Chen, Tao Zhang, Zhongwei Chen, Shengyuan Liu,Xiaolin Peng, Jianping Ma, Xiaohong Zhong, Yanqiong Yan, Linlin Tang,Yifeng Mai, Liyuan Han*, and Shiwei Duan*. Prediabetes is associated with HNF-4 alpha P2 promoter polymorphism rs1884613: a case-control study in Han Chinese population and an updated meta-analysis. Dis Markers. 2014. 2014: 231736
10、Yuan Li#, Qun Hong Wu*, Ming Li Jiao#, Xiao Hong Fan#, Quan Hu, Yan Hua Hao#, Ruo Hong Liu, Wei Zhang,Yu Cui, Li Yuan Han#. Gene–environment interaction between adiponectin gene polymorphisms and environmental factors on the risk of diabetic retinopathy.J Diabetes Invest J Diabetes Investig. 2015 Jan6(1):56-66.
11、Du Y,Han LY#,Li DD,Liu H,Gao YH,Sun DJ*.Associations Between XRCC1 Arg399Gln, Arg194Trp, and Arg280His Polymorphisms and Risk of Differentiated Thyroid Carcinoma: A Meta-analysis. Asian Pac J Cancer Prev.201314(9):5483-7.
12、He Y#,Han L#,Li W,Shu X,Zhao C,He Y,Bi M,Li Y*,Sun C*. Effects of the calcium-sensing receptor A986S polymorphism on serum calcium and parathyroid hormone levels in healthy individuals, Gene [J]. 2012( 491):110-1153.
13、Libo Liang, Qunhong Wu*, Lijun Gao,Yanhua Hao, Chaojie Liu, Yanguang Xie,Hong Sun, Xinglu Yan,Fabin Li,Honghai Li,Hongxia Fang,, Ning Ning,1 Yu Cui, Liyuan Han，Factors contributing to the high prevalence of multidrug-resistant tuberculosis: a study from China[J]. Thorax 2012 Jul67(7):632-8.
14、Wang CY,Chen ZW,Zhang T,Liu J,Chen SH,Liu SY,Han LY,Hui ZH,Chen YM*. Elevated plasma homocysteine level is associated with ischemic stroke in Chinese hypertensive patients. Eur J Intern Med.2014 Jul25(6):538-44. doi: 10.1016/j.ejim.2014.04.011. Epub 2014 May 11.
15、Fan X,Wu Q*,Li Y,Hao Y,Ning N,Kang Z,Cui Y,Liu R,Han L. Association of polymorphisms in the vascular endothelial growth factor gene and its serum levels with diabetic retinopathy in Chinese patients with type 2 diabetes: a cross-sectional study. Chin Med J (Engl). 2014. 127(4): 651-7.
16、Liu K,Lin X,Zhou Q,Ma T,Han L,Mao G,Chen J,Yue X,Wang H,Zhang L,Jin G,Jiang J,Zhao J*,Zou B*. The Associations between Two Vital GSTs Genetic Polymorphisms and Lung Cancer Risk in the Chinese Population: Evidence from 71 Studies. PLoS One.2014 Jul 189(7):e102372. doi: 10.1371/journal.pone.0102372. eCollection 2014.
17、Fan X,Wu Q*,Li Y,Hao Y,Ning N,Kang Z,Cui Y,Liu R,Han L.Association between adiponectin concentrations and diabetic retinopathy in patients with type 2 diabetes: a meta analysis. Chin Med J (Engl).2014127(4):765-71.
18、Li Yang, QunhongWu*, Yuan Li, Xiaohong Fan, Yanhua Hao, Hong Sun,Yu Cui, and Liyuan Han. Association of the Receptor for Advanced Glycation End Products Gene Polymorphisms and Circulating RAGE Levels with Diabetic Retinopathy in the Chinese Population. Journal of Diabetes Research. 2013. http://dx.doi.org/10.1155/2013/264579
19、Ji H,Wang Y,Liu G,Xu X,Dai D,Chen Z,Zhou D,Zhou X,Han L,Li Y,Zhuo R,Hong Q,Jiang L,Zhang X,Liu Y,Xu L,Chang L,Li J6,An P1,Duan S,Wang Q. OPRK1 promoter hypermethylation increases the risk of Alzheimer's disease. Neurosci Lett. 2015 Oct 8606:24-9. doi: 10.1016/j.neulet.2015.08.027. Epub 2015 Aug 20.
20、Liyuan Han*, Yanfen Liu*, Shiwei Duan, Benjamin Perry, Wen Li, and Yonghan He. DNA methylation and hypertension: emerging evidence and challenges . Briefings in Functional Genomics, 2016, 1–10 . doi: 10.1093/bfgp/elw014
21、Liyuan Han, Yanfen Liu, Changyi Wang, Linlin Tang , Xiaoqi Feng ,Thomas Astell-Burt, Qi wen, Donghui Duan, Nanjia Lu, Guodong Xu,Kaiyue Wang, Lu Zhang, Kaibo Gu, Sihan Chen, Jianping Ma, Tao Zhang, Dingyun You** , Shiwei Duan *. Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review. Clinical nutrition (Edinburgh, Scotland), 2016. http://dx.doi.org/10.1016/j.clnu.2016.11.011. 22、Jianping Ma#, Jufang Wang#, Yanfen Liu#, Changyi Wang#, Donghui Duan, Nanjia Lu, Kaiyue Wang, Lu Zhang, Kaibo Gu, Sihan Chen, Tao Zhang, Dingyun You,* and Liyuan Han,*. Comparisons of serum miRNA expression profiles in patients with diabetic retinopathy and type 2 diabetes mellitus. [J]. Clinics, 2017, 72(2):111.
23、Liyuan Han*, Yuanyuan Li*, Linlin Tang*, Zhongwei Chen, Tao Zhang, Sihan Chen,Shengyuan Liu, Xiaolin Peng, Yifeng Mai, Renjie Zhuo, Changyi Wang and Shiwei Duan. IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study. Experimental & Therapeutic Medicine, 2016, 12(3). DOI: 10.3892/etm.2016.3554.
24、劉艷芬，陸南佳，段東輝，段世偉，韓麗媛*，麥一峰*. 表觀遺傳DNA甲基化與糖尿病研究進展[J]. 生命科學研究, 2016, 20(3):271-277.DOI： 10.16605/j.cnki.1007-7847.2016.03.015
25、張愛平，汪燕，韓麗媛*.同型半胱氨酸與心腦血管疾病的研究進展[J].生命科學，2015，27(7)，DOI: 10.13376/j.cbls/2015126
學術組織名稱
級 別
所任職務
任職起止時間
浙江省流行病學青年委員會
省級
委員
2013.06—至今
浙江省預防醫學會
省級
會員
2013.06—至今
寧波市預防醫學會
市級
會員
2013.06—至今
寧波市全科醫學學會
市級
會員
2016.06—至今
1、國家自然科學基金，81402745，循環miRNAs調控糖尿病性視網膜病變新生血管形成的機制研究.2015-2017，23萬，在研，主持。
2、中國博士后自然科學基金面上項目，156458，Hcy代謝關鍵酶基因甲基化調控缺血性腦卒中的分子機制. 2015-2017，8萬，在研，主持。
3、教育部人文社科，14YJC630046，全民醫保評價指標體系構建及實證研究-—以浙江省為例.2015-2017，8萬，在研，主持。
4、江蘇省博士后基金，缺血性腦卒中的發病機制研究，2017 -2018，3萬，在研，主持。
5、浙江省自然科學基金，LY17H260002，DNA甲基化調控缺血性腦卒中的發病機制研究，2017至2019，10萬，在研，主持。
6、浙江省自然科學基金，LQ13H260002，循環miRNAs對2型糖尿病視網膜早期病變的預測研究.2013-2015，5萬，結題。
7、寧波市自然科學基金，2014A610268，糖尿病性視網膜病變循環miRNAs差異表達及其調控新生血管的機制研究，2014-2015，5萬，結題。
8、浙江省教育廳基金，Y201326971，血清脂聯素與糖尿病性視網膜病變的相關性研究.2013-2015，1萬，結題。
9、橫向項目，811600600，寧波大學-深圳市南山區慢性病防治院合作平臺。2015-2020，50萬元，在研，主持。
10、橫向項目，811602490，慢性病高危人群健康管理效果評估與研究。2016-2019，30萬元，在研，主持。
專利3項
1、可用于檢測2型糖尿病相關的PTPN1基因啟動子區甲基化程度的試劑盒及其應用(2015104289335).發明型專利. 2015.第一發明人
2、用于檢測2型糖尿病視網膜病變的miR-3197分子標記物及其擴增引物和應用(2015109809533).發明型專利. 2015.第一發明人
3、用于檢測2型糖尿病視網膜病變的miR-2116-5p分子標記物及其擴增引物和應用(2015109809800).發明型專利. 2015.第一發明人

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