中山大學附屬第三醫院導師：張琪 正文

　　姓名：張琪　 性別：女　　職稱：研究員　　
　　學院：附屬第三醫院　 　最后學歷：博士
　　主要研究方向：干細胞的基礎研究與臨床轉化應用 ；肝癌微環境、腫瘤生物治療

醫療專長:

　　肝膽外科常見疾病診治、腫瘤免疫細胞治療

獲獎情況:

　　獲全國百篇優秀博士學位論文獎勵、新世紀優秀人才支持計劃

論　　著:

1）Zhang Q, Chen G, Liu X, Qian Q. Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy. Cell Res. 2007 Feb;17(2):89-99.

2）Li T, Yang Y, Hua X, Wang G, Liu W, Jia C, Tai Y, Zhang Q※, Chen G. Hepatocellular Carcinoma-Associated Fibroblasts Trigger NK Cell Dysfunction via PGE2 and IDO. Cancer Lett. 2011 Dec 17. [Epub ahead of print]

3）Wang GY, Yang Y, Li H, Zhang J, Jiang N, Li MR, Zhu HB, Zhang Q※, Chen GH. A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation. PLoS One. 2011;6(9):e25295.

4）Chen W, Wu Y, Liu W, Wang G, Wang X, Yang Y, Chen W, Tai Y, Lu M, Qian Q, Zhang Q※, Chen G. Enhanced antitumor efficacy of a novel fiber chimeric oncolytic adenovirus expressing p53 on hepatocellular carcinoma. Cancer Lett. 2011;307(1):93-103.

5）Wang GY, Yang Y, Li H, Zhang J, Li MR, Zhang Q※, Chen GH. Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4(+) CD25(+) Foxp3(+) regulatory T cell expansion. Hepatol Res. 2012 ;42(2):192-202

6）ZHANG Ying-cai, ZHANG Qi※, LI Hua, ZHANG Jian, WANG Gen-shu, XU Chi, YI Shu-hong, YI Hui-min, CAI Chang-jie, LU Min-qiang, YANG Yang , CHEN Gui-hua. Prognostic factors for late mortality after liver transplantation for benign end-stage liver disease . Chin Med J (Engl). 2011,124:4229-35.

7）Lei J, Wang Z, Hui D, Yu W, Zhou D, Xia W, Chen C, Zhang Q, Wang Z, Zhang Q※, Xiang AP. Ligation of TLR2 and TLR4 on murine bone marrow-derived mesenchymal stem cells triggers differential effects on their immunosuppressive activity. Cell Immunol. 2011;271(1):147-56. Cell Immunol. 2011;271(1):147-56

8）ZHANG Qi, YANG Yang, ZHANG Jian, WANG Guo-ying, LIU Wei, QIU Dong-bo, HEI Zi-qing, YING Qi-long , CHEN Gui-hua. Efficient derivation of functional hepatocytes from mouse induced pluripotent stem cells by a combination of cytokines and sodium butyrate . Chin Med J (Engl). 2011,124:3786-93.

9）Zhang Q, Nie M, Sham J, Su C, Xue H, Chua D, Wang W, Cui Z, Liu Y, Liu C, Jiang M, Fang G, Liu X, Wu M, Qian Q. Effective gene-viral therapy for telomerase-positive cancers by selective replicative-competent adenovirus combing with endostatin gene. Cancer Res. 2004,64(15):5390-7.

10）Zhang Q, Chen G, Wang X, Peng L, Liu C, Yang Y, Su C, Wu H, Li L, Liu X, Wu M & Qian Q . Increased Safety with Preserved Antitumoral Efficacy on Hepatocellular Carcinoma with Dual-regulated Oncolytic Adenovirus. Clinical Cancer Research 2006;12(21), 6523-6531.

11）Jiang M, Shi W, Zhang Q (cofirst author), Wang X, Guo M, Cui Z, Su Ch, Yang Q, Li Y, Sham J, Liu X, Wu M, and Qian Q. Gene Therapy for Her2 over-expression cancers using adenovirus mediated full-length anti-Her2 antibody. Clinical Cancer Research 2006;12(20):6179-85

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